Submitted for Publication: January 31, 2013; final revision received May 2, 2013; accepted May 28, 2013.
Published Online: December 18, 2013. doi:10.1001/jamapsychiatry.2013.3181.
Study concept and design: Watanabe, Yahata, Kato, Kasai, Yamasue.
Acquisition of data: Watanabe, Abe, Kuwabara, Yahata, Takano, Iwashiro, Natsubori, Aoki, Takao, Kawakubo, Kamio, Kato, Yamasue.
Analysis and interpretation of data: Watanabe, Miyashita, Kasai, Yamasue.
Drafting of the manuscript: Watanabe, Kamio, Yamasue.
Critical revision of the manuscript for important intellectual content: Watanabe, Abe, Kuwabara, Yahata, Takano, Iwashiro, Natsubori, Aoki, Takao, Kawakubo, Kato, Miyashita, Kasai, Yamasue.
Statistical analysis: Watanabe, Yamasue.
Obtained funding: Watanabe, Kato, Kasai, Yamasue.
Administrative, technical, or material support: Abe, Kuwabara, Yahata, Takano, Aoki, Takao, Kawakubo, Kato, Miyashita, Kasai, Yamasue.
Study supervision: Kamio, Kato, Miyashita, Kasai, Yamasue.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by Grants-in-Aid for Scientific Research (KAKENHI) 22689034 (Dr Yamasue) and 20591378 (Dr Yahata) from the Japan Society for the Promotion of Science, by the Global Center of Excellence Program (Dr Yahata), and by grant 222882 from the Japan Society for the Promotion of Science Research Foundation for Young Scientists (Dr Watanabe).
Role of the Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Information: Part of this study is a result of the Development of Biomarker Candidates for Social Behavior project under the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
Additional Contributions: Uta Frith, PhD, provided comments on the manuscript, Markus Heinrichs, PhD, provided the composition of the placebo that he and his colleagues used, Hideyuki Inoue, MD, PhD, and Yasumasa Nippashi, MD, provided support in data collection, Motomu Suga, MD, PhD, supported data management, Yoshitsugu Yanagihara, PhD, composed the placebo, and Miho Kuroda, PhD, supported diagnosis.