Comment & Response |

Early Medication Discontinuation on Long-term Recovery Outcome in First-Episode Psychosis

Juan Undurraga, MD, PhD1; Andrea Murru, MD, PhD1; Eduard Vieta, MD, PhD1
[+] Author Affiliations
1Bipolar Disorders Unit, Neuroscience Institute, Hospital Clinic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Catalonia, Spain
JAMA Psychiatry. 2014;71(2):206-207. doi:10.1001/jamapsychiatry.2013.2993.
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To the Editor We read with interest the recently published study by Wunderink et al1 in this journal. It confirms previous evidence that drug-naive patients may respond to doses of antipsychotic medication at the lower end of the recommended range2 and goes further suggesting that patients in the dose reduction/discontinuation (DR) group have better long-term functional outcomes. Nevertheless, there are several methodological issues regarding that study as highlighted next.


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February 1, 2014
Christy L. M. Hui, PhD; Eric Y. H. Chen, MD
1Department of Psychiatry, University of Hong Kong, Hong Kong SAR, China
2State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China
JAMA Psychiatry. 2014;71(2):207-208. doi:10.1001/jamapsychiatry.2013.3697.
February 1, 2014
Lex Wunderink, MD, PhD; Sjoerd Sytema, PhD
1Department of Research and Education, Friesland Mental Health Services, Leeuwarden, the Netherlands2Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
2Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
JAMA Psychiatry. 2014;71(2):208-209. doi:10.1001/jamapsychiatry.2013.3530.
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