Comment & Response |

Early Medication Discontinuation on Long-term Recovery Outcome in First-Episode Psychosis

Christy L. M. Hui, PhD1; Eric Y. H. Chen, MD2
[+] Author Affiliations
1Department of Psychiatry, University of Hong Kong, Hong Kong SAR, China
2State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China
JAMA Psychiatry. 2014;71(2):207-208. doi:10.1001/jamapsychiatry.2013.3697.
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To the Editor Wunderink et al1 studied the long-term effects of early dosage reduction or discontinuation (DR) of antipsychotic medication vs maintenance treatment (MT) on recovery in patients with remitted first-episode psychosis. It makes an important contribution to the literature and has intriguing clinical implications. However, we would like to clarify some issues before concluding the longitudinal benefits of DR over MT in the study.


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February 1, 2014
Juan Undurraga, MD, PhD; Andrea Murru, MD, PhD; Eduard Vieta, MD, PhD
1Bipolar Disorders Unit, Neuroscience Institute, Hospital Clinic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Catalonia, Spain
JAMA Psychiatry. 2014;71(2):206-207. doi:10.1001/jamapsychiatry.2013.2993.
February 1, 2014
Lex Wunderink, MD, PhD; Sjoerd Sytema, PhD
1Department of Research and Education, Friesland Mental Health Services, Leeuwarden, the Netherlands2Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
2Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
JAMA Psychiatry. 2014;71(2):208-209. doi:10.1001/jamapsychiatry.2013.3530.
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