Submitted for Publication: August 20, 2013; final revision received January 2, 2014; accepted January 7, 2014.
Published Online: April 16, 2014. doi:10.1001/jamapsychiatry.2014.62.
Study concept and design: Feder, aan het Rot.
Acquisition, analysis, or interpretation of data: Feder, Parides, Murrough, Perez, Morgan, Saxena, Kirkwood, Lapidus, Wan, Iosifescu, Charney.
Drafting of the manuscript: Feder, Parides, Kirkwood.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Feder, Parides, Kirkwood.
Obtained funding: aan het Rot.
Administrative, technical, or material support: Murrough, Perez, Morgan, Saxena, aan het Rot, Lapidus, Wan.
Study supervision: Feder, Parides, Murrough, Perez, Iosifescu, Charney.
Conflict of Interest Disclosures: Dr Charney and the Icahn School of Medicine at Mount Sinai have been named on a use patent application of ketamine for the treatment of depression. If ketamine were shown to be effective in the treatment of depression and received approval from the US Food and Drug Administration for this indication, Dr Charney and Mount Sinai could benefit financially. In the present year, after study completion, Drs Charney and Feder and Mount Sinai were named on a use patent application of ketamine for the treatment of PTSD. If ketamine were shown to be effective in the treatment of PTSD and received approval from the US Food and Drug Administration for this indication, Drs Charney and Feder and Mount Sinai could benefit financially. No other disclosures are reported.
Funding/Support: This study was funded by grant W81XWH-08-1-0602 from the Department of the Army–US Army Medical Research Acquisition Activity (Dr Charney, principal investigator).
Role of the Sponsor: The funding agency had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Solara Calderon, BA, provided assistance with participant recruitment and ratings. Jazmin Moral, LCSW, provided assistance with clinical assessments and ratings. The Clinical Research Unit staff at Mount Sinai provided assistance with study procedures. Jess Brallier, MD, an anesthesiologist, provided occasional assistance with study procedures. They all received financial compensation.