Submitted for Publication: November 22, 2013; final revision received February 10, 2014; accepted March 6, 2014.
Published Online: May 14, 2014. doi:10.1001/jamapsychiatry.2014.453.
Study concept and design: Clementz, Sweeney, Tamminga, Keshavan.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Mathew, Gardin, Tandon, Eack, Seidman, Clementz, Keshavan.
Critical revision of the manuscript for important intellectual content: Mathew, Gardin, Tandon, Francis, Seidman, Clementz, Pearlson, Sweeney, Tamminga, Keshavan.
Statistical analysis: Mathew, Gardin, Tandon, Eack, Francis, Clementz, Keshavan.
Obtained funding: Pearlson, Sweeney, Tamminga, Keshavan.
Administrative, technical, or material support: Tandon, Francis, Seidman, Tamminga, Keshavan.
Study supervision: Pearlson, Sweeney, Tamminga, Keshavan.
Conflict of Interest Disclosures: Dr Pearlson has served on an advisory panel for Bristol-Myers Squibb. Dr Sweeney has served on advisory boards for Bristol-Myers Squibb, Eli Lilly, Pfizer, Roche, and Takeda and has received grant support from Janssen. Dr Tamminga has served on the advisory board for drug development for Intra-Cellular Therapies, Inc; has served as an ad hoc consultant for PureTech Ventures, Eli Lilly Pharmaceuticals, Sunovion, Astellas, Cypress Bioscience, and Merck; has served as an organizer and unpaid volunteer for the International Congress on Schizophrenia Research; has been a council member and unpaid volunteer for the National Alliance on Mental Illness; and has served as deputy editor for the American Psychiatric Association. Dr Keshavan has received research support from Sunovion and GlaxoSmithKline. No other disclosures were reported.
Funding/Support: This research was supported in part by grants MH078113, MH077945, MH077852, MH077851, MH077862, MH072767, and MH083888 from the National Institute of Mental Health and grant SCDMH82101008006 from the Commonwealth Research Center.
Role of the Sponsor: The funders reviewed the manuscript but had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Gunvant Thaker, Department of Psychiatry, University of Maryland, Baltimore, MD, Nashaat Boutros, MD, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, and Melvin McKinnis, MD, Department of Psychiatry, University of Michigan, Ann Arbor, provided collaboration on this project, and William Carpenter, MD, Department of Psychiatry, University of Maryland, Baltimore, made helpful suggestions. They received no compensation from the funders for these contributions.