Submitted for Publication: October 11, 2013; final revision received December 30, 2013; accepted January 24, 2014.
Published Online: May 21, 2014. doi:10.1001/jamapsychiatry.2014.138.
Study concept and design: Brody, Mukhin, Rose, Mandelkern.
Acquisition, analysis, or interpretation of data: Brody, Mukhin, Mamoun, Luu, Neary, Liang, Shieh, Sugar, Mandelkern.
Drafting of the manuscript: Brody, Luu, Mandelkern.
Critical revision of the manuscript for important intellectual content: Brody, Mukhin, Mamoun, Neary, Liang, Shieh, Sugar, Rose, Mandelkern.
Statistical analysis: Brody, Sugar, Mandelkern.
Obtained funding: Brody.
Administrative, technical, or material support: Brody, Mamoun, Luu, Neary, Liang, Shieh, Rose.
Study supervision: Brody, Mamoun, Mandelkern.
Conflict of Interest Disclosures: Dr Rose is principal investigator and Dr Mukhin is a coinvestigator on a grant from Philip Morris Inc for research unrelated to this study. Dr Rose also has a patent purchase agreement with Philip Morris International for nicotine inhalation technology unrelated to this study. No other disclosures were reported.
Funding/Support: This study was supported by grant R01 DA20872 from the National Institute on Drug Abuse (Dr Brody), grant 19XT-0135 from the Tobacco-Related Disease Research Program (Dr Brody), and Clinical Science Research and Development Merit Review Award I01 CX000412 from the Office of Research and Development, US Department of Veterans Affairs (Dr Brody).
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Shahrdad Lotfipour, PhD, University of California, Los Angeles, collected data on which the regional nondisplaceable volume of distribution values were calculated; he received no compensation from the funders for this contribution.