0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
In This Issue of JAMA Psychiatry |

Highlights FREE

JAMA Psychiatry. 2014;71(6):607. doi:10.1001/jamapsychiatry.2013.2733.
Text Size: A A A
Published online

RESEARCH

Lozier and colleagues used an implicit face-emotion processing paradigm to measure amygdala activity associated with callous-unemotional (CU) traits and externalizing behaviors in youths with conduct problems. They found amygdala responses to fearful expression were negatively associated with CU traits and positively associated with externalizing behaviors, and that reduced amygdala activity mediated the relationship between CU traits and proactive aggression.

Nurnberger and colleagues examined genome wide association data in the Psychiatric Genomics Consortium Bipolar Group for information regarding specific genes and neurobiologic pathways associated with bipolar disorder. A set of 226 empirically significant genes was identified, targeting hormonal regulation, calcium channels, second messenger systems, and glutamate signaling. Comparison with a brain gene expression data set implicated neuronal development pathways as well. These results reinforce specific neurobiologic hypotheses regarding bipolar disorder and may suggest new strategies for prevention and treatment.

Using high-resolution magnetic resonance spectroscopic imaging, Goh and colleagues detected significantly elevated brain lactate in individuals with autism spectrum disorder (ASD) (13%), with higher rates in adults (20%) than children (6%). In addition, by mapping lactate in small, contiguous voxels throughout the brain, they identified regions of the brain affected by mitochondrial dysfunction in ASD.

Feder and colleagues reported significant improvement in posttraumatic stress disorder (PTSD) symptom severity 24 hours after a single intravenous infusion of ketamine in patients with chronic PTSD compared with midazolam. Ketamine was also associated with improvement in comorbid depressive symptom severity and overall clinical presentation, with only transient dissociative symptoms.

By applying the classic twin design to a sample of 10 678 Australian twins, Maciejewski and colleagues found that individual differences in nonsuicidal self-injury and suicidal ideation are both substantially influenced by genetic and residual (including nonshared environmental) factors, while shared environment does not play a role. Furthermore, the substantial phenotypic correlation between both behaviors was largely driven by overlapping genetic influences, whereas overlapping residual influences accounted for the remainder.

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.