Submitted for Publication: December 4, 2013; final revision received January 20, 2014; accepted February 7, 2014.
Published Online: June 4, 2014. doi:10.1001/jamapsychiatry.2014.250.
Study concept and design: Rekkas, Sacher, Houle, Meyer.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Rekkas, Lee, Kish, Meyer.
Critical revision of the manuscript for important intellectual content: Rekkas, Wilson, Yogalingam, Sacher, Rusjan, Houle, Stewart, Kolla, Kish, Chiuccariello, Meyer.
Statistical analysis: Rekkas, Meyer.
Obtained funding: Rekkas, Sacher, Meyer.
Administrative, technical, or material support: Rekkas, Wilson, Lee, Sacher, Rusjan, Houle, Stewart, Kolla, Chiuccariello, Meyer.
Study supervision: Rekkas, Meyer.
Conflict of Interest Disclosures: Drs Wilson, Houle, and Meyer have received operating grant funds for other studies from Eli Lilly and Co, GlaxoSmithKline, Bristol-Myers Squibb, Lundbeck, and SK Life Science in the past 5 years. Dr Meyer has been a consultant to these companies as well as Takeda, Sepracor, Trius, Mylan, and Teva; is developing natural health products to treat high MAO-A states; is an inventor for patents to apply measures of MAO to diagnose or treat mood disorders; and is applying for additional similar patents. Dr Stewart is a scientific advisor to Eli Lilly and Co regarding the Cymbalta Pregnancy Registry and serves as an editor for the effects of SSRIs on the fetus in UpToDate.
Funding/Support: This work was supported by an operating grant and Canada Research Chair from the Canadian Institutes of Health Research, the NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation, the Canadian Foundation for Innovation, and the Ministry for Research and Innovation.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Previous Presentation: This work was presented in part at the 68th Annual Meeting of the Society of Biological Psychiatry; May 17, 2013; San Francisco, California.
Additional Contributions: From the Research Imaging Centre at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada, Cynthia Xu, MD, and Laura Miler, BSc, served as research coordinators, Leslie Romano, SSW, served as a research analyst, Alvina Ng, BSc, and Laura Nguyen, BSc, served as technicians, Jun Parkes, MSc, Armando Garcia, BSc, Winston Stableford, BSc, and Min Wong, BSc, served as chemistry staff, and Terry Bell, BSc, and Ted Harris-Brandts, BSc, served as engineers. The Canadian Institutes of Health Research provides some overhead funding to institutions, which may have supported the salary of some of these staff located at the Centre for Addiction and Mental Health. Also, the Canadian Institutes of Health Research funded other projects for which some people would have received salary support for their contributions.