Submitted for Publication: November 7, 2013; final revision received March 6, 2014; accepted March 12, 2014.
Published Online: July 23, 2014. doi:
Study concept and design: Lopes, Greenberg, Canteras, Leite, Norén, Rasmussen, Miguel.
Acquisition, analysis, or interpretation of data: Lopes, Greenberg, Canteras, Batistuzzo, Hoexter, Gentil, Pereira, Joaquim, de Mathis, D’Alcante, Taub, de Castro, Tokeshi, Sampaio, Shavitt, Diniz, Busatto, Miguel.
Drafting of the manuscript: Lopes, Greenberg, Gentil, Pereira, Joaquim, D’Alcante, Taub, Tokeshi, Leite, Rasmussen, Miguel.
Critical revision of the manuscript for important intellectual content: Lopes, Greenberg, Canteras, Batistuzzo, Hoexter, Gentil, Pereira, de Mathis, D’Alcante, Taub, de Castro, Sampaio, Shavitt, Diniz, Busatto, Norén, Miguel.
Statistical analysis: Pereira, Diniz, Rasmussen.
Obtained funding: Lopes, Busatto, Miguel.
Administrative, technical, or material support: Lopes, Greenberg, Canteras, Batistuzzo, Hoexter, Joaquim, de Mathis, de Castro, Tokeshi, Sampaio, Leite, Shavitt, Norén, Miguel.
Study supervision: Lopes, Greenberg, D’Alcante, Busatto, Norén, Miguel.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by grants to Drs Lopes and Miguel from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo Research Foundation; grants 1999/08560-6, 2005/55628-08, and 2011/21357-9) and from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, National Council for Scientific and Technological Development; grants 305548/2005-0 and 480196/2009-5). Dr Hoexter is supported by a postdoctoral scholarship from FAPESP (2013/16864-4).
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank Lawrence Scahill, MSN, PhD, of the Yale Child Study Center, for his advice and Victor Fossaluza, PhD, of the Department of Statistics, Federal University of São Carlos, and Soane M. Santos, MSc, of the Dante Pazzanese Institute, for their assistance with the statistical analyses. We also thank João V. Salvajoli, MD, PhD (Heart Hospital [HCor]), and Fernando S. Gouvea, MD (private practice), for their assistance with the medical evaluations, as well as the independent review board members (Christina H. Gonzalez, MD, PhD, Department of Psychiatry, Federal University of São Paulo; Luiz C. A. Alves, MD, private practice; Francisco Lotufo Neto, MD, PhD, Department of Psychiatry, University of São Paulo School of Medicine; and Cristina de Lucca, São Paulo Obsessive-Compulsive Disorder and Tourette Disorder Foundation) for their contributions to the study with respect to ethical and safety issues.