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Letters to the Editor |

Mania Induced by Withdrawal of Treatment With Interferon Alfa

Bernardo Carpiniello, MD; Maria Germana Orrù, MD; Antonella Baita, MD; Carmine M. Pariante, MD; Giulia Farci
Arch Gen Psychiatry. 1998;55(1):88-89. doi:.
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Patients treated with interferon alfa are frequently subject to mood disorders.1 This report describes 2 cases of mania subsequent to withdrawal of treatment with interferon alfa observed during a prospective study of a cohort of 44 patients affected by chronic hepatitis B receiving long-term treatment. Both subjects had normal findings on personal and family histories for psychiatric disorders.

McDonald  EMMann  AHThomas  HC Interferons as mediators of psychiatric morbidity. Lancet. 1987;211175- 1178
Wills  RJ Clinical pharmacokinetics of interferons. Clin Pharmacokinet. 1990;19390- 399
Pavol  MAMeyers  CARexer  JLValentine  ADMattis  PJTalpaz  M Patterns of neurobehavioural deficits associated with interferon alfa therapy for leukemia. Neurology. 1995;45947- 950
Gessa  GLPani  LFadda  PFratta  W Sleep deprivation in the rat: an animal model of mania. Eur Neuropsychopharmacol. 1995;5(suppl)89- 94

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