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Comment & Response |

Fixed-Effects Models and Diagnosing Psychiatric Disorders

Jeffrey Sonis, MD, MPH1
[+] Author Affiliations
1University of North Carolina at Chapel Hill
JAMA Psychiatry. 2014;71(9):1078. doi:10.1001/jamapsychiatry.2014.687.
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To the Editor D’Onofrio et al1 reported an increased risk for the development of offspring psychiatric disorders with advancing paternal age. For most of the disorders (except for attention-deficit/hyperactivity disorder [ADHD]), the curves for the fixed-effects models have a similar shape to the curves for the baseline (ie, crude) and adjusted models; however, in each case, the fixed-effects models showed much larger non-null effects. For ADHD, the fixed-effects models were the only ones that showed non-null (ie, odds ratio > 1) effects. These large and substantively meaningful differences between the fixed-effects models and the baseline and adjusted models raise concerns about the validity of the fixed-effects models.


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September 1, 2014
Gerhard B. Holt, BMBS, MBA, MSc, MS, BA
1Codman Group, Philadelphia, Pennsylvania
JAMA Psychiatry. 2014;71(9):1077-1078. doi:10.1001/jamapsychiatry.2014.564.
September 1, 2014
Brian M. D’Onofrio, PhD; Arvid Sjölander, PhD; Paul Lichtenstein, PhD
1Department of Psychological and Brain Sciences, Indiana University–Bloomington
2Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
JAMA Psychiatry. 2014;71(9):1078-1079. doi:10.1001/jamapsychiatry.2014.693.
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