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Comment & Response |

Fixed-Effects Models and Diagnosing Psychiatric Disorders—Reply

Brian M. D’Onofrio, PhD1; Arvid Sjölander, PhD2; Paul Lichtenstein, PhD2
[+] Author Affiliations
1Department of Psychological and Brain Sciences, Indiana University–Bloomington
2Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
JAMA Psychiatry. 2014;71(9):1078-1079. doi:10.1001/jamapsychiatry.2014.693.
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In Reply We appreciate having the opportunity to respond to Sonis’ concerns regarding our article on advancing paternal age (APA) at childbearing.1 The population and within-family estimates responded to different research questions. The population estimates examined how common it is that offspring born to fathers of different ages have psychopathology. On the other hand, the comparison of differentially exposed siblings and cousins using fixed-effects models examined the magnitude of the risk for psychopathology in offspring associated with paternal age while holding other factors constant.

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September 1, 2014
Gerhard B. Holt, BMBS, MBA, MSc, MS, BA
1Codman Group, Philadelphia, Pennsylvania
JAMA Psychiatry. 2014;71(9):1077-1078. doi:10.1001/jamapsychiatry.2014.564.
September 1, 2014
Jeffrey Sonis, MD, MPH
1University of North Carolina at Chapel Hill
JAMA Psychiatry. 2014;71(9):1078. doi:10.1001/jamapsychiatry.2014.687.
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