We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Impact of Dietary Benzoic Acid on Treatment Response in Schizophrenia—Reply

Guochuan E. Tsai, MD, PhD1,2
[+] Author Affiliations
1Department of Psychiatry, Harbor–UCLA Medical Center, Torrance, California
2Los Angeles Biomedical Research Institute, Harbor–UCLA Medical Center, Torrance, California
JAMA Psychiatry. 2014;71(11):1299. doi:10.1001/jamapsychiatry.2014.709.
Text Size: A A A
Published online


In Reply While commenting on our article published in JAMA Psychiatry,1 Glue et al raise the issue that “dietary benzoic acid intake may be a significant confounding variable that needs to be considered in interpreting the outcome of this study.” First, the double-blind placebo-controlled design confirmed that the add-on treatment of benzoate is much more efficacious than placebo in improving symptoms and cognition in schizophrenia. It is apparent that both groups had received benzoate from their daily intake of food and drink; however, the active treatment group received a 1000-mg sodium benzoate supplement a day, while the placebo group did not.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





November 1, 2014
Paul Glue, MD, FRCPsych; Christopher Gale, MPH, FRANZCP; Winsome Parnell, BHSc, MSc, PhD
1Department of Psychological Medicine, University of Otago, Dunedin, New Zealand2Department of Human Nutrition, University of Otago, Dunedin, New Zealand
JAMA Psychiatry. 2014;71(11):1298-1299. doi:10.1001/jamapsychiatry.2014.673.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...