Submitted for Publication: May 12, 2014; final revision received July 28, 2014; accepted August 5, 2014.
Published Online: December 10, 2014. doi:10.1001/jamapsychiatry.2014.2147.
Study concept and design: A. Moreno-De-Luca, Evans, Hanson, Myers, Challman, D. Moreno-De-Luca, Chung, Spiro, Martin, Ledbetter.
Acquisition, analysis, or interpretation of data: A. Moreno-De-Luca, Evans, Boomer, Hanson, Bernier, Goin-Kochel, Myers, Slane, Hare, Chung, Faucett, Martin, Ledbetter.
Drafting of the manuscript: A. Moreno-De-Luca, Evans, Boomer, Chung, Martin, Ledbetter.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: A. Moreno-De-Luca, Evans, Boomer, Slane, Hare.
Obtained funding: Hanson, Goin-Kochel, Chung, Faucett, Martin, Ledbetter.
Administrative, technical, or material support: Evans, Hanson, Goin-Kochel, D. Moreno-De-Luca, Hare, Chung, Spiro, Faucett, Martin, Ledbetter.
Study supervision: A. Moreno-De-Luca, Evans, Chung, Martin, Ledbetter.
Conflict of Interest Disclosures: Drs Chung and Spiro are part-time or full-time employees of the Simons Foundation. No other disclosures were reported.
Funding/Support: This study was supported by Simons Foundation Autism Research Initiative (SFARI) awards 216845 and 313100 from the Simons Foundation (Mr Faucett and Drs Martin and Ledbetter) and by grants RO1MH074090 (Drs Martin and Ledbetter), 5R25MH071584-07 (Dr D. Moreno-De-Luca), and 5T32MH19961-14 (Dr D. Moreno-De-Luca) from the National Institute of Mental Health.
Role of the Funder/Sponsor: The Simons Foundation is a private not-for-profit research and education organization that funds and participates in research related to autism through cooperative agreements, such as the Simons Variation in Individuals Project. The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Information: Approved researchers can obtain the Simons VIP population dataset described in this study by applying at https://ordering.base.sfari.org.
Additional Contributions: We thank all of the families at the participating Simons Variation in Individuals Project (VIP) sites and the Simons VIP working group. We appreciate obtaining access to phenotypic data on the SFARI Base.