IN THIS issue of the ARCHIVES, Dr Nancy Andreasen1 proposes a "unitary" neural circuit–cognitive dysfunction model for understanding schizophrenia. This commentary will review Andreasen's scholarly article with a focus on (1) the continued search for specific neural circuit abnormalities in schizophrenia and their associated "signature" cognitive deficits; (2) how these neural circuit dysfunctions and cognitive deficits relate to the heterogeneity of schizophrenia disorder(s); and (3) the problem of the testing and falsifiability of the cortico-cerebellar-thalamic-cortical circuit (CCTCC) cognitive dysmetria model and whether any single unitary model is likely to account for the widespread functional and structural deficits of schizophrenia. At the end of the exercise of connecting the "dots" of brain dysfunction, will we end up with one or multiple (potentially overlapping) pictures of abnormal neural circuits in schizophrenia? I believe that the answer is the latter—that no single unitary model of neural circuit–cognitive dysfunction will be validated for this heterogeneous disorder. It is, of course, possible that a unitary view will prevail, and that is why I agree with Andreasen that much more research is needed in this complex area of inquiry.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and
Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early
dhildhood mortality and growth failure data and their association with maternal
Thank you for submitting a comment on this article. It will be reviewed by JAMA Psychiatry editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 16
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Users' Guides to the Medical Literature
Users' Guides to the Medical Literature
All results at
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.