In total, 561 subjects (18.4%) died during the follow-up of, on average, 50 months. In univariate analysis, significant predictors (P<.01) of mortality were advanced age (P<.001), male sex (P<.001), low level of education (P<.001), high urbanization level (P=.002), presence of all specific chronic diseases except arthritis (P<.001), physical disability (P<.001), current smoking (P=.02), low or high BMI (P=.04 and P=.003, respectively), and physical inactivity (P<.001). The crude mortality rate per 1000 person-years was 39.5 for the nondepressed, 71.4 for persons with minor depression, and 60.7 for those with major depression (Table 2). Persons with minor depression had a significant 1.84-fold higher risk of dying than nondepressed persons (95% confidence interval [CI], 1.49-2.27). This risk was reduced somewhat after adjustment for sex and age (relative risk [RR], 1.65; 95% CI, 1.33-2.04). However, the age-adjusted mortality risk of minor depression was much higher in men (RR, 2.02; 95% CI, 1.53-2.67) than in women (RR, 1.27; 95% CI, 0.92-1.76) (Figure 1). The significance of this interaction by sex was tested by adding the sex×minor depression interaction term in the age- and sex-adjusted model. Since the interaction term was statistically significant (P=.05), the remainder of the findings for minor depression will be presented for men and women separately. For major depression, the unadjusted mortality risk was 1.55 (95% CI, 0.92-2.58). Adjustment for sex and age increased the mortality risk to 2.32 (95% CI, 1.38-3.89) (Figure 1). No interaction by sex was present for major depression (P of interaction term, .53).