IN THIS issue of the ARCHIVES, Kahn et al1 summarize the findings of their analysis of primary and supervisory review documents and memoranda, authored by Food and Drug Administration clinical and statistical staff, that were obtained under the Freedom of Information Act from the files of 7 antidepressant New Drug Applications approved between 1987 and 1997. The authors undertook their analysis in an effort to determine whether there was any evidence within the agency's reviews of the comprehensive reports that drug sponsors make to the Food and Drug Administration to support the suspicion/belief, widely prevalent among those who question the ethical propriety of placebo-controlled trials, that patient-subjects randomized to placebo are at greater risk of injury and/or suffer greater substantive discomfort than those assigned to other experimental treatment conditions.
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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