0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Commentary |

Suicide and Antidepressant Treatment

Robert M. A. Hirschfeld, MD
Arch Gen Psychiatry. 2000;57(4):325-326. doi:10.1001/archpsyc.57.4.325.
Text Size: A A A
Published online

Extract

A QUICK scan of the article by Kahn et al1 might lead the casual reader to conclude that antidepressant treatment does not reduce the risk of suicide. However, a careful analysis of the data shows that any such conclusion would be unfortunate and unsubstantiated, and that several important questions remain unanswered.

The article examines data from clinical trials that were submitted to the Food and Drug Administration as parts of 5 successful applications for indications in the treatment of depression. Among the 19 639 patients who participated in the trials, 34 committed suicide during the 4- to 8-week periods in which the trials were conducted. The authors, assuming a completely linear event-time relationship, converted this into an estimated annual rate of 757 suicides per 100 000 depressed patients treated with 1 of the 5 antidepressants. This suicide rate is nearly 70 times higher than the rate in the general population. The article indicates that this falls within the range of the estimated depressed patient suicide rates (between 275 per 100 000 and 1352 per 100 000) that the authors have found in the literature. Also, a community study in Sweden (the "Lundby" study) followed people for 25 years and found the annual suicide rate for men with a history of depression to be 650 per 100 000.2 In men whose depression caused severe impairment, the annual rate soared to 3900 per 100 000.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 15

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();