This article was corrected | View correction
IN THIS issue of Archives of General Psychiatry, Suhara et al1 suggest that dopamine (DA) D2 receptors in the anterior cingulate cortex (ACCX) are significantly reduced in drug-naïve patients with schizophrenia as compared with healthy controls, and that in the same subjects, D2 binding in that region correlates negatively with positive symptom scores on the Brief Psychiatric Rating Scale. This was based on positron emission tomography (PET) measurements of the "binding potential" (BP) of D2 receptors using the positron-emitting D2 (and D3 ) receptor radioligand [11C] FLB457. Binding potential is a common outcome measure that is widely used as a surrogate of Bmax (receptor density) but is influenced by several factors, including intrasynaptic DA concentration. In fact, the BP measurement carried out by PET was assumed to be a conglomerate of receptor parameters(not directly measured), including the absolute D2 DA Bmax in the brain, a free fraction of the unbound and dissociation constants of the radioligand, and the free concentration and dissociation constants of the competing endogenous DA. There was no significant correlation between BP and the negative symptoms or between BP and the age of onset or the duration of illness.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
Thank you for submitting a comment on this article. It will be reviewed by JAMA Psychiatry editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 16
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
The Rational Clinical Examination
Among Patients With Headaches, Who Should Have Neuroimaging?
The Rational Clinical Examination
Assessing the Likelihood of a Significant Neuroimaging Intracranial Abnormality
All results at
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.