Left temporal auditory P300 amplitude reduction is associated with reduced gray matter volume of the left posterior superior temporal gyms (LPSTG) in chronic schizophrenia. To determine whether this association was present at first episode and specific to schizophrenia, McCarley et al Article
evaluated healthy normal controls and patients with schizophrenia and affective (mainly manic) psychosis at first hospitalization. Specific to schizophrenia were findings of P300 left temporal amplitude reduction, LPSTG matter volume reduction, and LPSTG–left temporal P300 correlation. These data suggest that interrelated functional and structural temporal lobe abnormalities are specific and critical features of both early and chronic schizophrenia.