As shown in Figure 3C, regions of statistically thinner cortex in patients relative to controls (at P<.001 uncorrected; equivalent to P<.05 corrected, shown in yellow) included the orbitofrontal cortices bilaterally (approximate Brodmann areas [BAs] 10 and 11), the left inferior frontal gyrus (approximate BAs 44 and 45), the right medial frontal cortex (approximate BAs 32 and 24), the left occipitotemporal junction (approximate BAs 22, 21, and 37), the right medial temporal cortex (approximate BAs 28, 27, 34, and 35), and the left inferior temporal gyrus (approximate BA 20). All these regions except for the right orbitofrontal and right medial frontal cortices showed significant differences when the average thickness across the entire cortex in each individual was included as an additional covariate. At a subthreshold significance level (P<.05, uncorrected, shown in red) thinning in the patients was also observed in the right inferior frontal cortex (BAs 44, 45, and 47), the dorsolateral prefrontal cortex bilaterally (approximate BAs 8, 9, and 46), the left anterior medial frontal cortex (approximate BAs 32 and 24), the right inferior temporal cortex (approximate BA 20), the left medial temporal lobe (approximate BAs 27, 28, 34, and 35), the temporal poles bilaterally (approximate BAs 20 and 38), the fusiform gyri bilaterally (BA 37), and the left insula. These regions did not show significant differences in thickness when we covaried for the average thickness across the entire cortex in each individual. Even at P<.05 uncorrected, the superior parietal cortex and primary visual, somatosensory, and motor cortices appeared to be relatively spared. Moreover, although our tests were 2-tailed, the amount of thinning was overwhelmingly greater than thickening in the patients compared with the controls, ie, even at P<.05 uncorrected, virtually no false-positive findings were detected for thickening.