0
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 50.19.47.197. Please contact the publisher to request reinstatement.
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
In This Issue of JAMA Psychiatry |

Highlights FREE

JAMA Psychiatry. 2015;72(1):1. doi:10.1001/jamapsychiatry.2014.1858.
Text Size: A A A
Published online

RESEARCH

Applying individual participant data meta-analysis to 3 pivotal randomized clinical trials in acute schizophrenia (n = 611) and 3 randomized clinical trials in predominantly negative schizophrenia (n = 475), Furukawa and colleagues found that for both types of schizophrenia, the more severe the baseline symptoms, the greater the differences between the active treatment and placebo. Towards the mildest end of the spectrum, patients benefit less in terms of symptom improvement but may experience full adverse effects of antipsychotics.

Kiosses and colleagues found that in 74 older adults with major depression and cognitive impairment to the level of moderate dementia, problem-adaptation therapy, a home-delivered psychosocial intervention, increased emotion regulation and improved depression and disability more than supportive therapy. Thirty-eight percent of participants in problem-adaptation therapy achieved full remission of depression and an additional 25% achieved partial remission. In addition, problem-adaptation therapy improved depression in patients who had failed 1 adequate trial of an antidepressant (n = 31).

Using data from a 10-year longitudinal study of preschool-onset major depressive disorder, Belden and colleagues examined anterior insula volume as a biomarker for recurrent depression. Schoolchildren with a history of preschool-onset major depressive disorder had significantly reduced insula volume compared with healthy peers. The association between preschool-onset major depressive disorder and reduced insula volume was driven by the symptom of early pathological guilt. Smaller anterior insula volume predicted an increased likelihood of major depressive disorder recurrence postscan.

Hahn and colleagues applied machine learning to functional magnetic resonance imaging data to predict treatment response to cognitive behavioral therapy in panic disorder with agoraphobia. Prognostic markers were derived from regional and whole-brain gaussian process classifiers using a nested leave-one-out cross-validation. Integrating regional classifiers yielded good predictive performance (accuracy, 82 %; sensitivity, 92 %; and specificity, 72 %), showing that response prediction based on functional magnetic resonance imaging data is possible with high accuracy on a single-subject level.

Safer and colleagues analyzed national data of physician office–based visits for youth, finding that DSM-IV subthreshold not otherwise specified (NOS) diagnoses rose significantly between 1999 and 2010 for composite mood disorder NOS, anxiety disorder NOS, and bipolar disorder NOS compared with those psychiatric diagnoses achieving full criteria. When attention-deficit/hyperactivity disorder diagnoses were excluded, NOS diagnoses from 2007 to 2010 accounted for 56% of all psychiatric diagnoses in youth.

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

1,456 Views
0 Citations
×

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs