Submitted for Publication: April 28, 2014; final revision received August 29, 2014; accepted September 2, 2014.
Published Online: January 28, 2015. doi:10.1001/jamapsychiatry.2014.2427.
Study concept and design: Setiawan, Wilson, Houle, Meyer.
Acquisition, analysis, or interpretation of data: Setiawan, Mizrahi, Rusjan, Miler, Rajkowska, Suridjan, Kennedy, Rekkas, Houle, Meyer.
Drafting of the manuscript: Setiawan, Meyer.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Setiawan, Rekkas, Meyer.
Obtained funding: Setiawan, Houle, Meyer.
Administrative, technical, or material support: Wilson, Mizrahi, Rusjan, Miler, Suridjan, Kennedy, Houle, Meyer.
Study supervision: Meyer.
Conflict of Interest Disclosures: Drs Wilson, Houle, and Meyer have received operating grant funds for other studies from Bristol-Myers Squibb, Eli Lilly and Company, GlaxoSmithKline, Lundbeck, and SK Life Sciences in the past 5 years. Dr Meyer has been a consultant to Mylan, Sepracor, Takeda, Teva, and Trius. None of these companies participated in the design or execution of this study or in the writing of the manuscript. No other disclosures were reported.
Funding/Support: This study was supported by an operating grant (principal investigator, Dr Meyer), a fellowship (Dr Setiawan), and a Canada Research Chair (Dr Meyer) from the Canadian Institutes of Health Research, by a National Alliance for Research in Schizophrenia and Affective Disorders Young Investigator Grant from the Brain and Behavior Research Foundation (Dr Setiawan), by grant P30 GM103328 from the National Institutes of Health (Dr Rajkowska), and by the Canadian Foundation for Innovation and the Ontario Ministry for Research and Innovation (infrastructure).
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Previous Presentations: This paper was presented in part at the 52nd Annual Meeting of the American College of Neuropsychopharmacology; December 9, 2013; Hollywood, Florida; at the 69th Annual Meeting of the Society of Biological Psychiatry; May 8, 2014; New York, New York; and at the 53rd Annual Meeting of the American College of Neuropsychopharmacology; December 8, 2014; Phoenix, Arizona.
Additional Contributions: Cynthia Xu, MD, Research Imaging Centre, Centre for Addiction and Mental Health, coordinated research for this study. Ian Fan, BSc, Research Imaging Centre, Centre for Addiction and Mental Health, provided research assistance. Nathan Kolla, MD, Research Imaging Centre, Centre for Addiction and Mental Health, Institute of Medical Science, University of Toronto assisted with recruitment and medical coverage. Andrea Tyrer, BSc, Research Imaging Centre, Centre for Addiction and Mental Health and Department of Pharmacology, University of Toronto assisted with recruitment. Alvina Ng, BSc, and Laura Nguyen, BSc, worked as study technicians. Jun Parkes, MSc, Armando Garcia, BSc, Winston Stableford, BSc, and Min Wong, BSc, Research Imaging Centre, served as chemistry staff. Terry Bell, BSc, and Ted Harris-Brandts, BSc, Research Imaging Centre, provided engineering support. Dr. Kolla was funded from the Canadian Institutes of Health research and Ms Tyrer was funded by Brain Canada; all other contributors are paid employees of the Centre for Addiction and Mental Health.
Correction: This article was corrected on March 4, 2015, to fix Table 2.