Davidson et alArticle report the results of a 6-month, multicenter trial of extended-release venlafaxine in posttraumatic stress disorder (PTSD). The drug was superior to placebo on core PTSD symptoms, resilience, daily function, quality of life, and vulnerability to the effects of daily stress. Rates of remission were 51% for drug and 37% for placebo at the end of treatment. Resilience took longer to improve than did core PTSD symptoms. Drug superiority was maintained throughout the full treatment period (ie, beyond 12 weeks).