0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
This Month in Archives of General Psychiatry |

This Month in Archives of General Psychiatry FREE

Arch Gen Psychiatry. 2009;66(10):1043. doi:10.1001/archgenpsychiatry.2009.135.
Text Size: A A A
Published online

Donohoe et al (Article examined the effects on cognition of the NOS1 variant rs6490121, identified in a recent genome-wide association study as a potential schizophrenia risk variant. In large Irish samples, the risk genotype was found to be associated with clinically significant variation in both verbal IQ and working memory both in patients with schizophrenia and healthy participants. These findings were then replicated in large independent German samples of both patients and healthy participants.

Holliday et alArticle applied latent class analysis to identify clinically homogeneous subtypes in 1236 Han Chinese individuals with schizophrenia. Two of the 4 identified groups demonstrated familial aggregation and were used as alternative phenotypes in genome-wide linkage analyses. A deficit subtype characterized by severe negative symptoms and pronounced functional impairment showed genome-wide significant linkage to chromosome 1q23-25.

Perry et alArticle used a novel Behavioral Pattern Monitor to identify distinctive exploratory phenotypes in patients with bipolar mania and schizophrenia. Patients with bipolar mania demonstrated a unique pattern of increased activity and object exploration. In parallel tests in mice, pharmacological and genetic reductions in the dopamine transporter produced a similar behavioral pattern.

Simon et alArticle examined the long-term benefits and costs of 2 programs to improve depression treatment in primary care: a telephone care management program to improve antidepressant treatment and a telephone program including care management and cognitive behavioral psychotherapy. The care management program had greater costs than benefits, even if a day free of depression was valued at $20. In contrast, the program including psychotherapy had greater benefits than costs if a day free of depression was valued at $9 or more.

Sánchez-Villegas et alArticle found that a greater adherence to the Mediterranean dietary pattern significantly reduced the incidence of depression among 10 094 healthy middle-aged adults of the Spanish Seguimiento Universidad de Navarra cohort. Inverse dose-response relationships were found for fruits and nuts and legumes.

Shin et alArticle used positron emission tomography and a twin design to determine whether functional neuroimaging abnormalities in posttraumatic stress disorder (PTSD) are acquired characteristics or familial risk factors. Combat veterans with PTSD and their trauma-unexposed identical co-twins had greater metabolic activity in the dorsal anterior cingulate/midcingulate cortex than veterans without PTSD and their identical co-twins. Hypermetabolism in this region appears to represent a familial risk factor for developing PTSD after trauma exposure.

Oral naltrexone hydrochloride effectively antagonizes heroin, but its clinical utility is limited by patient noncompliance; sustained-release preparations may overcome this limitation. Hulse et alArticle showed that treatment with a long-acting sustained-release naltrexone implant improved clinical efficacy compared with oral naltrexone, with significantly more of the patients treated with oral naltrexone than the naltrexone implant returning to regular heroin use by 6 months.

Martell et alArticle report that an anticocaine vaccine produced high (≥43 μg/mL) IgG anticocaine antibody levels in 21 of 55 methadone-maintained, cocaine-dependent subjects completing a 24-week, randomized, double-blind trial. These 21 subjects had more cocaine-free urine samples than 47 subjects who took placebo or 34 subjects with low IgG anticocaine antibody levels who completed 24 weeks (45% vs 35%). The proportion of subjects having 50% reduction in cocaine use also was significantly greater in the subjects with a high IgG level than a low IgG level (0.53 vs 0.23).

Love et alArticle examined interindividual variations in the traits impulsiveness and deliberation and how they relate to the functional response of the endogenous opioid neurotransmitter system to an experimental stressor. Opioid receptor concentrations and measures of endogenous function as obtained with neuroimaging techniques predict a high proportion of the variability of personality traits deliberation and impulsiveness.

Bellgrove et alArticle examined whether a common haplotype of the dopamine transporter gene, a replicated risk factor for attention-deficit/hyperactivity disorder (ADHD), could predict patterns of attentional impairment in children with ADHD. DAT1 haplotype status strongly predicted impairments of spatial selective attention, with impairment being greatest in children with ADHD who were homozygous for the risk haplotype.

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

222 Views
0 Citations
×

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs