We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
This Month in Archives of General Psychiatry |

This Month in Archives of General Psychiatry FREE

Arch Gen Psychiatry. 2010;67(10):982. doi:10.1001/archgenpsychiatry.2010.120.
Text Size: A A A
Published online

To investigate epistasis within the NRG1 schizophrenia risk pathway, Nicodemus et al applied machine learning algorithms to a genetic case-control study and defined significant 2-way interactions between single-nucleotide polymorphisms within NRG1 and between NRG1 and its receptor ERBB4 and a 3-way interaction between single-nucleotide polymorphisms in NRG1, ERBB4, and AKT1. All 3 interactions were biologically validated using functional magnetic resonance imaging in an independent sample of healthy controls; carriers of risk-associated genotypes showed significantly less efficient processing in the dorsolateral prefrontal cortex during the N-back task.

In an outpatient sample (n = 289), van Tol et al reported on a generic reduction of the rostral anterior cingulate gyrus in major depressive disorder and/or frequently occurring anxiety disorders, while controlling for illness severity, selective serotonin use, and sex. Furthermore, early onset of depression was associated with subgenual prefrontal reductions.

Depressive symptoms during pregnancy have been inconsistently reported to be associated with an increased risk of preterm birth (<37 weeks' gestation), low birth weight (<2500 g), and intrauterine growth restriction (<10th percentile for gestational age). In a meta-analysis of 29 prospective studies, Grote et al observed that pregnant women with depression are at increased risk for preterm birth and low birth weight neonates, although the effect size varies by depression measurement, country location, and socioeconomic status within the United States.

Lock et al conducted a multisite randomized controlled trial of 121 adolescents with anorexia nervosa comparing family-based treatment and adolescent-focused individual therapy. Those treated with family-based treatment had greater changes in body mass index percentiles and eating-related psychopathology at the end of treatment and higher rates of full remission at follow-up.

Halmøy et al investigated the long-term consequences of maternal serotonin deficiency on offspring behavior. After identifying families with functional variants in the genes for the serotonin-synthesizing enzymes tryptophan hydroxylase 1 and tryptophan hydroxylase 2, they showed that offspring of mothers with tryptophan hydroxylase 1 mutations had 1.5 to 2.5 times higher symptom scores of attention-deficit/hyperactivity disorder than random controls or offspring of fathers carrying the corresponding mutations.

Chronis-Tuscano et al found that young children with attention-deficit/hyperactivity disorder were at greatly increased risk for depression and suicide attempts during adolescence. Among children with attention-deficit/hyperactivity disorder, girls, children with depressed mothers, and children with more symptoms of other mental disorders at 4 to 6 years of age were at greatest risk for adverse outcomes.

Barnea-Goraly et al used diffusion tensor imaging to investigate white matter structure in children with autism, their unaffected siblings, and controls. Compared with the control group, both the autism and sibling groups had widespread, significantly aberrant white matter structure in the frontal parietal and temporal lobes, including regions important for social cognition.

Denys et al used a double-blind crossover design with randomly assigned 2-week periods of active and sham stimulation to determine whether bilateral deep brain stimulation of the nucleus accumbens is an effective and safe treatment for therapy-refractory obsessive-compulsive disorder. The results suggest that stimulation of the accumbens may be an effective treatment of refractory obsessive-compulsive disorder.

Acamprosate, an approved alcoholism treatment, has an unknown mechanism of action. Animal studies suggest that it might act by dampening a hyperglutamatergic state. In this issue, Umhau et al used magnetic resonance spectroscopy to examine this hypothesis by scanning alcohol-dependent subjects on days 4 and 25 of abstinence. Measures of central glutamate increased over time in the placebo group but were markedly suppressed in acamprosate-treated subjects.

In this study, Cuijpers et al calculated the economic costs of neuroticism in a large representative sample of the Dutch general population. The per capita excess costs of neuroticism were surprisingly high. The total costs of neuroticism per million inhabitants resulting from the 25% highest scorers ($1.393 billion) were about 2.5 as high as the excess costs of common mental disorders ($585 million).





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Related Content

Customize your page view by dragging & repositioning the boxes below.