The 5D-ASC demonstrated marked subjective differences between the psilocybin and placebo experiences. Psilocybin particularly affected the oceanic boundlessness (F1,11 = 33.12, P < .001) and visionary restructuralization (F1,11 = 18.95, P = .001) dimensions (Figure 2A). Psilocybin had smaller but significant effects on anxious ego dissolution (F1,11 = 4.91, P = .049) and auditory alterations (F1,11 = 5.93, P = .03). The item clusters with marked differences between the subjective states produced by psilocybin and niacin included a significant increase (P < .05) in psilocybin-invoked states of positive derealization, positive depersonalization, altered sense of time, positive mood, manialike experiences, elementary hallucinations, visual pseudohallucinations, synesthesia, changed meaning of percepts, facilitated recollection, and facilitated imagination. Subscales with no appreciable differences between intrasubjective states induced by the 2 treatments included anxious derealization, thought disorder, delusion, fear of loss of thought control, and fear of loss of body control (Figure 2B).