Submitted for Publication: June 23, 2014; final revision received October 27, 2014; accepted October 28, 2014.
Published Online: March 4, 2015. doi:10.1001/jamapsychiatry.2014.3008.
Study concept and design: Pierce, Courchesne.
Acquisition, analysis, or interpretation of data: Pramparo, Pierce, Lombardo, Marinero, Courchesne.
Drafting of the manuscript: Pramparo, Pierce, Lombardo, Xu, Courchesne.
Critical revision of the manuscript for important intellectual content: Pierce, Lombardo, Xu, Courchesne.
Statistical analysis: Xu.
Administrative, technical, or material support: Pierce, Carter Barnes, Ahrens-Barbeau, Murray, Lopez.
Study supervision: Pierce, Xu, Courchesne.
Conflict of Interest Disclosures: Drs Pramparo and Courchesne reported a patent pending that includes data from this study. No other disclosures were reported.
Funding/Support: This research was supported by grants P50-MH081755 and R01-MH036840 (Dr Courchesne), R01-MH080134 (Dr Pierce), 1U54RR025204-01 (Mr Marinero), and 1UL1RR031980-01 (Dr Xu) from the National Institutes of Health and by grant KL2TR00099 from the University of California, San Diego Clinical and Translational Research Institute (Dr Pramparo).
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Roxana Hazin, PhD, at the UC San Diego Autism Center of Excellence helped with participant recruitment. We thank all the families for making this study possible.