Submitted for Publication: June 8, 2014; final revision received November 7, 2014; accepted November 9, 2014.
Published Online: March 18, 2015. doi:10.1001/jamapsychiatry.2014.3020.
Study concept and design: Wheeler, Szeszko, Lerch, Voineskos.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Wheeler, Voineskos.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Wheeler, Chakravarty, Lerch, Linke, Voineskos.
Obtained funding: Wheeler, Wessa, Chakravarty, Mulsant, Malhotra, Voineskos.
Administrative, technical, or material support: Szeszko, Foussias, Chakravarty, DeRosse, Remington, Malhotra, Voineskos.
Study supervision: Szeszko, Malhotra, Voineskos.
Conflict of Interest Disclosures: Dr Foussias has served on advisory boards for Roche and has received speaker fees from Lundbeck, Novartis, and Roche. Dr Remington has received consultancy fees from Neurocrine, Novartis, and Synchroneuron as well as research and speaker fees from Novartis. Dr Mulsant has received research support in the form of medications for National Institutes of Health–funded clinical trials from Bristol-Myers Squibb, Eli Lilly and Company, and Pfizer. Dr Malhotra has served as a consultant for Genomind Inc. No other disclosures were reported.
Funding/Support: Work from Zucker Hillside Hospital was supported by grant P50MH080173 from the National Institute of Mental Health (NIMH). Work from the Centre for Addiction and Mental Health (CAMH) was supported in part by the CAMH Foundation thanks to the Kimel Family, Koerner New Scientist Award, and Paul E. Garfinkel New Investigator Catalyst Award, as well as the Brain and Behavior Research Foundation, Canadian Institutes of Health Research, Ontario Mental Health Foundation, and grant R01MH099167 from the NIMH. Work from Heidelberg was supported by the Deutsche Forschungsgemeinschaft (grant SFB636/C6, We3638/3-1).
Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Correction: This article was corrected on March 25, 2015, to fix a caption.