Submitted for Publication: July 23, 2014; final revision received November 6, 2014; accepted December 22, 2014.
Published Online: April 1, 2015. doi:10.1001/jamapsychiatry.2014.3188.
Study concept and design: All authors.
Acquisition, analysis, or interpretation of data: Finkelstein, Macdonald, Hollands, Sivilotti, Hutson, Mamdani, Juurlink.
Drafting of the manuscript: Finkelstein, Macdonald, Hollands, Sivilotti, Hutson, Juurlink.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Finkelstein, Macdonald, Hollands, Hutson, Mamdani, Koren.
Obtained funding: Juurlink.
Administrative, technical, or material support: Finkelstein, Macdonald, Hutson, Juurlink.
Study supervision: Finkelstein, Sivilotti, Juurlink.
Conflict of Interest Disclosures: Dr Mamdani reports serving on advisory boards and/or receiving honoraria from AstraZeneca, Bristol-Myers Squibb, Eli Lilly and Company, GlaxoSmithKline, Hoffman–La Roche, Novartis AG, Novo Nordisk, and Pfizer. No other disclosures were reported.
Funding/Support: This study was supported by an Emerging Teams grant from the Canadian Institutes of Health Research, grant 92247 from the Canadian Drug Safety and Effectiveness Research Network (Drs Juurlink and Mamdani), and the Institute for Clinical Evaluative Sciences, a nonprofit research institute sponsored by the Ontario Ministry of Health and Long-Term Care.
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: The Canadian Drug Safety and Effectiveness Research Network (CDSERN) group members were Colin R. Dormuth, ScD, Therapeutics Initiative, Pharmacology and Therapeutics, and Department of Anesthesiology, University of British Columbia, Vancouver, Canada; Collette B. Raymond, PharmD, MSc, Department of Community Health Sciences and Manitoba Center for Health Policy, University of Manitoba, Winnipeg, Canada; Anita Kozyrskj, PhD, Department of Pediatrics, University of Alberta, Edmonton, Canada; Yola Moride, PhD, Faculty of Pharmacy, Université de Montréal, Montréal, Canada; and Michael Paterson MSc, Chronic Disease and Pharmacotherapy, Institute for Clinical Evaluative Sciences, Toronto, Canada.
Disclaimer: The opinions, results, and conclusions reported in this article are those of the authors and are independent from the funding sources. No endorsement by the Institute for Clinical Evaluative Sciences or the Ontario Ministry of Health and Long-Term Care is intended or should be inferred.
Additional Contributions: Brogan Inc, Ottawa, provided the Drug Product and Therapeutic Class Database.