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Invited Commentary |

Promoting Healthy Brain Aging

Charles F. Reynolds III, MD1,2,3
[+] Author Affiliations
1Geriatric Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
2Behavioral and Community Health Sciences, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
3Department of Psychiatry and Neurology, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
JAMA Psychiatry. 2015;72(6):619-620. doi:10.1001/jamapsychiatry.2015.0174.
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The co-occurrence of diabetes mellitus and depression, especially in persons younger than 65 years, poses an important hazard to healthy brain aging and cognitive fitness in the later years of life. Katon and colleagues1 from Denmark contribute this key observation in this issue of JAMA Psychiatry.

This observation raises questions about the biology of aging and about promotion of ways of aging well, not just living a long life. First, with respect to the basic biology of aging, how does aging enable disease? Second, from the perspective of population health, how can we narrow the gap between life span and health span, compressing the period of functional morbidity (especially related to dementia) in the later years of life? The answers to the first question will likely provide important clues for answering the second.2

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