Submitted for Publication: July 25, 2014; final revision received January 20, 2015; accepted January 22, 2015.
Published Online: April 29, 2015. doi:10.1001/jamapsychiatry.2015.0137.
Study concept and design: Cannon.
Acquisition, analysis, or interpretation of data: O’Hanlon, Leemans, Kelleher, Roddy, Harley, Hoscheit, Tiedt, Tabish, McGettigan, Frodl, Cannon.
Drafting of the manuscript: O’Hanlon, Kelleher, Clarke, Coughlan, Cannon.
Critical revision of the manuscript for important intellectual content: O’Hanlon, Leemans, Kelleher, Clarke, Coughlan, Harley, Amico, Hoscheit, Tiedt, Tabish, McGettigan, Frodl, Cannon.
Statistical analysis: O’Hanlon, Kelleher, Clarke, Cannon.
Obtained funding: Cannon.
Administrative, technical, or material support: Leemans, Harley, Frodl, Cannon.
Study supervision: Frodl, Cannon.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was funded by grants HRA/PHS/2-012/28 (Dr O’Hanlon) and HRA/PHS/2010/4 (Drs Roddy, Harley, and Amico) from the Health Research Board, Ireland. Dr Leemans was supported by grant 639.072.411 from the Netherlands Organization for Scientific Research. Dr Kelleher was supported in part by the European Community’s Seventh Framework Programme under grant HEALTH-F2-2010-241909 9 (European Network of National Schizophrenia Networks Studying Gene-Environment Interaction). Ms Coughlan was supported by Interdisciplinary Capacity Enhancement Award ICE/2012/11 from the Health Research Board, Ireland (to Drs Clarke and Cannon). Mr Hoscheit was supported by the Science Foundation Ireland’s Summer Programme for Undergraduate Research on Neuroscience. Dr Tiedt was funded by a Health Research Board, Summer Studentship. Dr Tabish was supported by a Royal College of Surgeons Summer Studentship. Dr Cannon was supported by Clinician Scientist Award CSA/2004/1 from the Health Research Board, Ireland, which also supported Dr Kelleher.
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Sojo Joseph (Trinity College Institute of Neuroscience radiographer) and Trinity College High Performance Computing assisted with the study. We acknowledge the use of the facilities of the Clinical Research Centre in the Royal College of Surgeons in Ireland Education and Research Centre. We would like to thank all the young participants and their parents for giving their time to this study.