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Anti-inflammatory Intervention in Depression

Harris A. Eyre, MBBS1,2; Bernhard T. Baune, PhD, MD, MPH, FRANZCP1
[+] Author Affiliations
1Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia
2Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
JAMA Psychiatry. 2015;72(5):511. doi:10.1001/jamapsychiatry.2014.3128.
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To the Editor We acknowledge the important work published by Köhler et al.1 This meta-analysis explored the clinical antidepressant effects of anti-inflammatories. The article found 14 randomized clinical trials and noted anti-inflammatory treatments (nonsteroidal anti-inflammatory drugs and cytokine inhibitors) reduce depressive symptoms vs placebo. The authors stated that the findings provide a proof of concept concerning anti-inflammatory treatments in depression; however, a high risk for bias and heterogeneity was noted.


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May 1, 2015
Victoria M. Leavitt, PhD; James F. Sumowski, PhD
1The Neurological Institute of New York, Columbia University Medical Center, New York
2Kessler Foundation Research Center, West Orange, New Jersey
JAMA Psychiatry. 2015;72(5):511-512. doi:10.1001/jamapsychiatry.2014.3132.
May 1, 2015
Rebecca Anglin, MD, PhD; Paul Moayyedi, MB, ChB, PhD; Grigorios I. Leontiadis, MD, PhD
1Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada2Department of Medicine (Gastroenterology), McMaster University, Hamilton, Ontario, Canada
2Department of Medicine (Gastroenterology), McMaster University, Hamilton, Ontario, Canada
JAMA Psychiatry. 2015;72(5):512. doi:10.1001/jamapsychiatry.2014.3246.
May 1, 2015
Ole Köhler, MD; Michael Eriksen Benros, MD, PhD; Jesper Krogh, MD
1Research Department P, Aarhus University Hospital, Risskov, Denmark2The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
3Mental Health Centre Copenhagen, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
JAMA Psychiatry. 2015;72(5):512-513. doi:10.1001/jamapsychiatry.2014.3186.
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