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Measuring the Effects of Treatment With Antipsychotics

Roberto Lozano, PhD1
[+] Author Affiliations
1Department of Pharmacy, Hospital Real de Nuestra Señora de Gracia, Zaragoza, Spain
JAMA Psychiatry. 2015;72(5):514. doi:10.1001/jamapsychiatry.2014.3130.
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To the Editor In their article in JAMA Psychiatry, Rutherford et al1 observed that the average change associated with placebo treatment in antipsychotic trials has risen since 1960. Moreover, they reported that the average difference between drug and placebo outcomes has significantly decreased over time, with reduced baseline severity and greater study duration. To evaluate drug efficacy in patients with schizophrenia, Rutherford et al1 used a standardized mean change score, which was determined by dividing the mean pre-post difference by the number of total possible points of the scale being used. Overall, they attributed their findings to modifications in randomized clinical trials that have contributed to inflated baseline scores, enrollment of less severely ill patients, and higher expectations of the study participants.


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May 1, 2015
Cynthia O. Siu, PhD; Ofer Agid, MD; Gary Remington, MD, PhD
1COS and Associates Limited, Central, Hong Kong, China
2Department of Psychiatry, Center for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
JAMA Psychiatry. 2015;72(5):514-515. doi:10.1001/jamapsychiatry.2014.3134.
May 1, 2015
Gad Mayer, MD; Uri Nitzan, MD; Pesach Lichtenberg, MD
1Shalvata Mental Health Center, Sackler School of Medicine at Tel-Aviv University, Tel Aviv, Israel
2Department of Psychiatry, Herzog Hospital, and the Hebrew University of Jerusalem, Jerusalem, Israel
JAMA Psychiatry. 2015;72(5):513-514. doi:10.1001/jamapsychiatry.2014.3136.
May 1, 2015
Bret R. Rutherford, MD; Melanie M. Wall, PhD; Steven P. Roose, MD
1Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York
JAMA Psychiatry. 2015;72(5):515-516. doi:10.1001/jamapsychiatry.2014.3184.
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