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Comment & Response |

Anti-inflammatory Intervention in Depression

Victoria M. Leavitt, PhD1; James F. Sumowski, PhD2
[+] Author Affiliations
1The Neurological Institute of New York, Columbia University Medical Center, New York
2Kessler Foundation Research Center, West Orange, New Jersey
JAMA Psychiatry. 2015;72(5):511-512. doi:10.1001/jamapsychiatry.2014.3132.
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To the Editor We read with interest the meta-analysis of randomized clinical trials providing support for anti-inflammatory treatment of depression that was published in JAMA Psychiatry by Köhler and colleagues.1 The meta-analysis highlighted the heterogeneity of results across studies, and it is unclear how anti-inflammatory treatment achieves its antidepressant effects. Given the well-established concurrence of depression and fatigue, one hypothesis is that the beneficial effect of anti-inflammatory treatment on depression may be mediated at least in part by treatment effects to reduce fatigue. Patients who feel less fatigued are likely to report less depression, particularly as measured by depression inventories with items that conflate the 2 constructs. Indeed, nonsteroidal anti-inflammatory drug treatment (aspirin) effectively lowers fatigue in patients with relapsing-remitting multiple sclerosis, even when controlling for depression.2


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May 1, 2015
Harris A. Eyre, MBBS; Bernhard T. Baune, PhD, MD, MPH, FRANZCP
1Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia2Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
1Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia
JAMA Psychiatry. 2015;72(5):511. doi:10.1001/jamapsychiatry.2014.3128.
May 1, 2015
Rebecca Anglin, MD, PhD; Paul Moayyedi, MB, ChB, PhD; Grigorios I. Leontiadis, MD, PhD
1Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada2Department of Medicine (Gastroenterology), McMaster University, Hamilton, Ontario, Canada
2Department of Medicine (Gastroenterology), McMaster University, Hamilton, Ontario, Canada
JAMA Psychiatry. 2015;72(5):512. doi:10.1001/jamapsychiatry.2014.3246.
May 1, 2015
Ole Köhler, MD; Michael Eriksen Benros, MD, PhD; Jesper Krogh, MD
1Research Department P, Aarhus University Hospital, Risskov, Denmark2The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
3Mental Health Centre Copenhagen, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
JAMA Psychiatry. 2015;72(5):512-513. doi:10.1001/jamapsychiatry.2014.3186.
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