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Measuring the Effects of Treatment With Antipsychotics

Cynthia O. Siu, PhD1; Ofer Agid, MD2; Gary Remington, MD, PhD2
[+] Author Affiliations
1COS and Associates Limited, Central, Hong Kong, China
2Department of Psychiatry, Center for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
JAMA Psychiatry. 2015;72(5):514-515. doi:10.1001/jamapsychiatry.2014.3134.
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To the Editor Rutherford et al1 concluded that (1) the standardized mean change (SMC) associated with medication treatment has decreased since 1960 and (2) that attributable causes included “inflation of baseline scores, enrollment of less severely ill participants, and higher expectations of patients.”

Unfortunately, the authors failed to consider other key factors affecting treatment effect size including features associated with the 2 publication periods (1965-1984 vs 1992-2012),2 efficacy and tolerability profiles specific to the individual antipsychotics,3 SMC from the control group,4 and/or the precision of individual trial results.2,4


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May 1, 2015
Roberto Lozano, PhD
1Department of Pharmacy, Hospital Real de Nuestra Señora de Gracia, Zaragoza, Spain
JAMA Psychiatry. 2015;72(5):514. doi:10.1001/jamapsychiatry.2014.3130.
May 1, 2015
Gad Mayer, MD; Uri Nitzan, MD; Pesach Lichtenberg, MD
1Shalvata Mental Health Center, Sackler School of Medicine at Tel-Aviv University, Tel Aviv, Israel
2Department of Psychiatry, Herzog Hospital, and the Hebrew University of Jerusalem, Jerusalem, Israel
JAMA Psychiatry. 2015;72(5):513-514. doi:10.1001/jamapsychiatry.2014.3136.
May 1, 2015
Bret R. Rutherford, MD; Melanie M. Wall, PhD; Steven P. Roose, MD
1Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York
JAMA Psychiatry. 2015;72(5):515-516. doi:10.1001/jamapsychiatry.2014.3184.
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