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Measuring the Effects of Treatment With Antipsychotics

Gad Mayer, MD1; Uri Nitzan, MD1; Pesach Lichtenberg, MD2
[+] Author Affiliations
1Shalvata Mental Health Center, Sackler School of Medicine at Tel-Aviv University, Tel Aviv, Israel
2Department of Psychiatry, Herzog Hospital, and the Hebrew University of Jerusalem, Jerusalem, Israel
JAMA Psychiatry. 2015;72(5):513-514. doi:10.1001/jamapsychiatry.2014.3136.
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To the Editor The findings by Rutherford et al1 suggest that the average treatment change associated with placebo treatment in antipsychotic trials has increased since 1960, while the change associated with medication treatment decreased. In trying to explain these findings, their discussion focused on methodological matters, such as study design and population, but overlooked another likely confounding factor: the transition from first-generation antipsychotics to second-generation antipsychotics during the last 3 decades.


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May 1, 2015
Roberto Lozano, PhD
1Department of Pharmacy, Hospital Real de Nuestra Señora de Gracia, Zaragoza, Spain
JAMA Psychiatry. 2015;72(5):514. doi:10.1001/jamapsychiatry.2014.3130.
May 1, 2015
Cynthia O. Siu, PhD; Ofer Agid, MD; Gary Remington, MD, PhD
1COS and Associates Limited, Central, Hong Kong, China
2Department of Psychiatry, Center for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
JAMA Psychiatry. 2015;72(5):514-515. doi:10.1001/jamapsychiatry.2014.3134.
May 1, 2015
Bret R. Rutherford, MD; Melanie M. Wall, PhD; Steven P. Roose, MD
1Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York
JAMA Psychiatry. 2015;72(5):515-516. doi:10.1001/jamapsychiatry.2014.3184.
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