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Comment & Response |

Anti-inflammatory Intervention in Depression—Reply

Ole Köhler, MD1,2; Michael Eriksen Benros, MD, PhD3; Jesper Krogh, MD3
[+] Author Affiliations
1Research Department P, Aarhus University Hospital, Risskov, Denmark
2The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
3Mental Health Centre Copenhagen, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
JAMA Psychiatry. 2015;72(5):512-513. doi:10.1001/jamapsychiatry.2014.3186.
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In Reply We read with interest the letters to the editor concerning our study,1 extending this important debate. The aim of our study was to review all randomized placebo-controlled clinical trials on the effect of anti-inflammatory intervention on depression, depressive symptoms, and adverse effects. The systematic review identified 14 trials, including 6262 patients, and the meta-analysis associated anti-inflammatory treatment with significant antidepressant treatment effect. Nonsteroidal anti-inflammatory drugs (NSAIDs), in particular the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, showed adjunctive antidepressant effects, whereas results on cytokine inhibitors did not alone reach significance. Thus, the clinical potential of the conducted trials and their results support a proof of concept of anti-inflammatory intervention in depression.

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May 1, 2015
Harris A. Eyre, MBBS; Bernhard T. Baune, PhD, MD, MPH, FRANZCP
1Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia2Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
1Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia
JAMA Psychiatry. 2015;72(5):511. doi:10.1001/jamapsychiatry.2014.3128.
May 1, 2015
Victoria M. Leavitt, PhD; James F. Sumowski, PhD
1The Neurological Institute of New York, Columbia University Medical Center, New York
2Kessler Foundation Research Center, West Orange, New Jersey
JAMA Psychiatry. 2015;72(5):511-512. doi:10.1001/jamapsychiatry.2014.3132.
May 1, 2015
Rebecca Anglin, MD, PhD; Paul Moayyedi, MB, ChB, PhD; Grigorios I. Leontiadis, MD, PhD
1Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada2Department of Medicine (Gastroenterology), McMaster University, Hamilton, Ontario, Canada
2Department of Medicine (Gastroenterology), McMaster University, Hamilton, Ontario, Canada
JAMA Psychiatry. 2015;72(5):512. doi:10.1001/jamapsychiatry.2014.3246.
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