We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
In This Issue of JAMA Psychiatry |

Highlights FREE

JAMA Psychiatry. 2015;72(5):409. doi:10.1001/jamapsychiatry.2014.1882.
Text Size: A A A
Published online


The etiology of autism spectrum disorder is complex. Colvert and colleagues used data from a population-based twin sample that included the full clinical spectrum of autism spectrum disorder to study the relative contribution of genetic and environmental factors. For 4 different clinical measures of autism spectrum disorder, they found evidence for substantial genetic influences, with heritability estimates ranging from 56% to 95%, and moderate nonshared environmental influences.

The effectiveness of treating alcohol use disorder with the opioid antagonist naltrexone has been linked to a functional polymorphism (Asn40Asp) of the µ-opioid receptor gene. Oslin and colleagues conducted a 12-week double-blind randomized clinical trial of naltrexone versus placebo, which revealed a significant reduction in heavy drinking across all groups and no evidence of an Asn40Asp genotype × treatment interaction. The Asn40Asp polymorphism is not a biomarker to predict the response to naltrexone treatment of alcohol dependence.

Antipsychotic medications are associated with increased mortality in older adults with dementia. In a retrospective case-control study of 46 008 medication users with dementia who were 65 years or older, Maust and colleagues found an increased mortality risk for individuals receiving antipsychotic medication, ranging from 3.8% for haloperidol to 2.0% for quetiapine. As a group, atypical antipsychotics showed a dose-response increase in mortality risk, with 3.5% greater mortality in the high-dose group.

Many individuals in the general population have psychotic experiences but it is not clear if they show the neural abnormalities seen in psychotic disorders. Wolf and colleagues used functional magnetic resonance imaging to examine brain activation patterns during a working memory and emotion identification task in a population-based sample of 260 youth individuals with psychosis spectrum features and 220 matched typically developing youth individuals (11-22 years of age). Functional abnormalities observed in the psychosis spectrum group were similar to those seen in individuals with or at risk for schizophrenia.

Dialectical behavior therapy (DBT) is a multicomponent evidenced-based treatment for individuals with borderline personality disorder; however, it remains unknown which of the components is most important for treatment success. Linehan and colleagues compared standard DBT treatment with treatment with either DBT skills training or individual DBT therapy in 99 women with borderline personality disorder. While all treatments were equally effective at reducing suicidal ideation and suicide attempts, treatments that contained skills training were superior for treatment adherence and reducing depression and anxiety.




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Related Content

Customize your page view by dragging & repositioning the boxes below.