Submitted for Publication: February 9, 2015; final revision received May 20, 2015; accepted June 17, 2015.
Published Online: August 19, 2015. doi:10.1001/jamapsychiatry.2015.1324.
Study concept and design: Smagula, Butters, Anderson, Lenze, Mulsant, Reynolds.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Smagula, Anderson, Lenze, Dew.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Smagula, Anderson, Dew, Reynolds.
Obtained funding: Butters, Lenze, Mulsant, Reynolds.
Administrative, technical, or material support: Butters, Lenze, Mulsant, Lotrich, Reynolds.
Study supervision: Anderson, Dew, Mulsant, Lotrich, Aizenstein, Reynolds.
Conflict of Interest Disclosures: Dr Butters reported serving as a consultant for GlaxoSmithKline, for whom she participated in diagnostic consensus conferences related to a clinical trial. No other disclosures were reported.
Funding/Support: This work was supported by grants R01 MH083660 (University of Pittsburgh), R01 MH083648 (Washington University in St Louis), and R01 MH 083643 (Center for Addiction and Mental Health, University of Toronto) from the National Institute of Mental Health, center core grant P30 MH90333 from the National Institute of Mental Health, and the UPMC Endowment in Geriatric Psychiatry from the University of Pittsburgh Medical Center. Dr Smagula was supported by research training grants T32 AG000181 and T32 MH019986 from the National Institute of Mental Health. Dr Lenze was supported by the Taylor Family Institute for Innovative Psychiatric Research.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Dr Smagula thanks his doctoral committee for their contribution to this work. Bobby L. Jones, PhD, University of Pittsburgh, Pittsburgh, Pennsylvania, provided expert consultation regarding the statistical methods used; he received no compensation.