We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Viewpoint |

Replacing DSM Categorical Analyses With Dimensional Analyses in Psychiatry Research The Research Domain Criteria Initiative

Cindy M. Yee, PhD1,2; Daniel C. Javitt, MD, PhD3,4; Gregory A. Miller, PhD1,2
[+] Author Affiliations
1Department of Psychology, University of California, Los Angeles
2Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles
3Department of Psychiatry, Columbia University, New York, New York
4Nathan Kline Institute for Psychiatric Research, Orangeburg, New York
JAMA Psychiatry. 2015;72(12):1159-1160. doi:10.1001/jamapsychiatry.2015.1900.
Text Size: A A A
Published online


This Viewpoint supports adoption of the Research Domain Criteria (RDoC) initiative to replace categorical with dimensional diagnoses.

Do we need to replace categorical with dimensional diagnoses to make progress in psychiatry research? Mostly.

The 1950s was a golden era for psychopharmacology. Within short order, sedatives such as meprobamate (Miltown) became available for the treatment of anxieties, monoamine oxidase inhibitors for depressions, and neuroleptics for psychoses. The mechanisms of action of these compounds were efficiently traced to their effects at specific targets using then-emergent neuroscientific methods. Perhaps even more importantly than their immediate utility, these treatments ushered in an era of optimism that the chaotic psychiatric diagnoses of the day could be codified and defined according to relevant biological characteristics: schizophrenia became unmoored from its Kraepelinian/Bleulerian roots and was effectively the disease that responded to antipsychotics, depression became the disease that responded to antidepressants, anxiety was a disease that responded to anxiolytics, and bipolar disorder was the disease that responded to lithium therapy.

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

7 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles