Using DSM-IV definitions of drug use disorders, national survey data indicate that prevalences may have increased. Grant and colleagues used National Epidemiologic Survey on Alcohol and Related Conditions–III, a cross-sectional representative survey of the United States, to assess the prevalence of drug use disorders and several psychiatric disorders using DSM-5 criteria. Prevalences of 12-month and lifetime drug use disorders were 3.9% and 9.9%, respectively. Drug use disorders were significantly associated with other substance use disorders and several psychiatric disorders. Among respondents with lifetime drug use disorders, only 24.6% received treatment.