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Editorial |

The Schizophrenia Polygenic Risk Score To What Does It Predispose in Adolescence?

Kenneth S. Kendler, MD1,2,3
[+] Author Affiliations
1Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond
2Department of Psychiatry, Virginia Commonwealth University, Richmond
3Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond
JAMA Psychiatry. 2016;73(3):193-194. doi:10.1001/jamapsychiatry.2015.2964.
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The initial goal of genome-wide association studies (GWASs) of psychiatric disorders was to identify individual genetic variants that predispose to illness. Along the way, another application of GWAS data was discovered1: the polygenic risk score (PRS). The concept is simple. We start with all single-nucleotide polymorphisms (SNPs) assessed in a training sample. In this issue of JAMA Psychiatry, Jones et al2 report findings using the second Psychiatric Genomics Consortium schizophrenia GWAS as that sample.3

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