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Comment & Response |

Quality of Life of Adult Patients With Attention-Deficit/Hyperactivity Disorder Taking Methylphenidate—Reply

Alexandra Philipsen, MD1; Ludger Tebartz van Elst, MD2; Erika Graf, PhD3
[+] Author Affiliations
1Medical Campus University of Oldenburg, School of Medicine and Health Sciences, Psychiatry and Psychotherapy–University Hospital, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany
2Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany
3Clinical Trials Unit, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany
JAMA Psychiatry. 2016;73(5):534-535. doi:10.1001/jamapsychiatry.2016.0051.
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In Reply We thank Boesen and Gøtzsche for recognizing our research efforts and for the opportunity to respond to their letter on our article.1

First and foremost, Boesen and Gøtzsche criticize the article for omitting detailed information on adverse events (AEs) and quality-of-life data. However, we believe the wealth of data this challenging landmark trial generated, if presented in detail, would require more space than is available in our presentation of the main results—the 2 × 2 design required reporting for both psychotherapeutic and medical interventions.1 Therefore, we had planned to publish separate reports on AEs and further secondary outcomes, including quality of life, and they are currently in preparation. We made this clear by stating that the secondary outcomes included those reported in JAMA Psychiatry1 and by referring readers to the publication of the study protocol.2 Although we appreciate the interest in further results, their absence from the current report is not owing to reporting bias.


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May 1, 2016
Kim Boesen, MD; Peter C. Gøtzsche, DMSci
1The Nordic Cochrane Centre, Copenhagen, Denmark
JAMA Psychiatry. 2016;73(5):533-534. doi:10.1001/jamapsychiatry.2016.0049.
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