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Comment & Response |

Measures of Psychosis Proneness and Genetic Risk for Schizophrenia—Reply

Hannah J. Jones, PhD1,2; Stanley Zammit, MRCPsych, PhD1,3
[+] Author Affiliations
1Centre for Academic Mental Health, School of Social and Community Medicine, University of Bristol, Bristol, England
2Medical Research Centre Integrative Epidemiology Unit, University of Bristol, Bristol, England
3MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, Wales
JAMA Psychiatry. 2016;73(6):638-639. doi:10.1001/jamapsychiatry.2016.0241.
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In Reply We thank van Os for his interest in our article.1 We agree that the evidence of association between schizophrenia genetic risk and negative symptoms, but not with psychotic experiences, could be due to greater measurement error when assessing psychotic experiences, as stated in the Discussion section of our article.1

However, we believe it is unlikely that the Community Assessment of Psychic Experiences (CAPE) self-report questionnaire negative symptom items are a more valid marker of psychotic experiences than the semi-structured Psychosis-Like Symptom Interview (PLIKSI). During the PLIKSI, individuals are assessed by psychology graduates trained in assessment using the Schedules for Clinical Assessment in Neuropsychiatry psychosis section and the interview itself shows very good interrater and test-retest reliability.2,3 Semi-structured interviews, as used in clinical practice, allow a more valid assessment of psychotic experiences than self-report questionnaires. Furthermore, given the similarity between the CAPE positive dimension and the PLIKS questionnaire (PLIKSq) (both contain items relating to bizarre experiences, perceptual abnormalities, paranoid ideations, and grandiosity and wording is similar, for example, “Do you ever see objects, people or animals that other people cannot see?” [CAPE] and “Have you ever seen something or someone that other people could not see?” [PLIKSq]), it is unlikely that schizophrenia genetic risk would be associated with CAPE psychotic experiences (via the negative symptom dimension as a proxy) and not the PLIKSq (see eFigure 2 in the Supplement of our article).1


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June 1, 2016
Jim van Os, MD, PhD
1Department of Psychiatry and Psychology, EURON, Maastricht University Medical Centre, Maastricht, the Netherlands2King’s College London, King’s Health Partners, Department of Psychosis Studies, Institute of Psychiatry, London, England
JAMA Psychiatry. 2016;73(6):638. doi:10.1001/jamapsychiatry.2016.0227.
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