We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Use of Clozapine in Schizophrenia—Reply ONLINE FIRST

Myrto T. Samara, MD1; Stefan Leucht, MD1
[+] Author Affiliations
1Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany
JAMA Psychiatry. Published online July 20, 2016. doi:10.1001/jamapsychiatry.2016.1331
Text Size: A A A
Published online


In Reply We disagree with the comment by Mustafa that meta-analysis as a method is the reason for the unexpected results in our article.1 Meta-analysis is just reflecting the results of the included studies. Our meta-analysis confirmed that clozapine is better than first-generation antipsychotics. The unexpected finding that it is not better than second-generation antipsychotics would come exactly the same from a narrative reviewer of these trials as well; the blinded randomized evidence supporting the superiority of clozapine compared with other second-generation antipsychotics is currently insufficient.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





July 20, 2016
Feras Ali Mustafa, MD
1Northamptonshire Healthcare NHS Foundation Trust, Northampton, England
JAMA Psychiatry. Published online July 20, 2016.;():. doi:10.1001/jamapsychiatry.2016.0976.
July 20, 2016
Joseph P. McEvoy, MD
1Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta
JAMA Psychiatry. Published online July 20, 2016.;():. doi:10.1001/jamapsychiatry.2016.1241.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...