We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Research Letter |

Association of Systemic Inflammation With Risk of Completed Suicide in the General Population

G. David Batty, DSc1; Steven Bell, PhD2; Emmanuel Stamatakis, PhD3; Mika Kivimäki, PhD1
[+] Author Affiliations
1Department of Epidemiology and Public Health, University College London, London, England
2Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
3Charles Perkins Centre and Prevention Research Collaboration, Sydney School of Public Health, University of Sydney, Sydney, Australia
JAMA Psychiatry. 2016;73(9):993-995. doi:10.1001/jamapsychiatry.2016.1805.
Text Size: A A A
Published online


This study uses UK national survey data to investigate the association between C-reactive protein levels and risk of suicide.

There is a growing prima facie case for inflammation being associated with suicide. In cohort studies,1 elevated levels of inflammatory markers have been linked to the future occurrence of depression, a known risk factor for suicide. In psychiatric patients, inflammation is positively associated with the intensity of self-reported suicidal ideation,2 and those who commit suicide have higher cytokine levels post mortem relative to control patients.3 Furthermore, individuals with asthma, a condition characterized by inflammation, experience higher rates of suicide mortality than their nonatopic counterparts.4

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Suicide Death Rates According to C-Reactive Protein (CRP) Level and Duration of Follow-up

The proportion of deaths by suicide in each of the 3 CRP categories (low [<1 mg/L], intermediate [1-3 mg/L], or high [>3 mg/L]) over the duration of follow-up (0-17 years). Each step signals at least 1 death by suicide. To convert to nanomoles per liter, multiply by 9.524.

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Original Article: What Is Causing This Patient's Vaginal Symptoms?

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis