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Comment & Response |

Hyperthermia for Major Depressive Disorder? ONLINE FIRST

Michael Berk, MD, PhD1,2; Susannah Tye, PhD3,4; Ken Walder, PhD5; Sean McGee, PhD5
[+] Author Affiliations
1IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia
2Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, the Florey Institute of Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
3Translational Neuroscience Lab, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota
4Department of Psychiatry, University of Minnesota, Minneapolis
5Molecular and Medical Research SRC, School of Medicine, Faculty of Health, Deakin University, Waurn Ponds, Victoria, Australia
JAMA Psychiatry. Published online September 14, 2016. doi:10.1001/jamapsychiatry.2016.1532
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To the Editor In their article in JAMA Psychiatry, Janssen and colleagues1 describe an intriguing pilot study showing that whole-body hyperthermia was superior to sham in reducing depression. Their conjecture was that warm-sensitive afferent thermosensory pathways affect mood regulatory neural activity.1 However, these data support an alternate hypothesis, which is that depression is associated with dysregulated mitochondrial function, the extent of which correlates with symptom severity and is associated with decreased oxidative energy generation and cerebral glucose use. Multiple psychiatric disorders are associated with a shift from aerobic to glycolytic energy generation. If it is shown that a therapy that increases mitochondrial energy generation also improves depressive symptoms, this would be useful, albeit indirect, proof of principle of this hypothesis.

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September 14, 2016
Max Fink, MD; Edward Shorter, PhD
1Stony Brook University School of Medicine, Saint James, New York
2University of Toronto, Medicine, History of Medicine Program, Toronto, Ontario, Canada
JAMA Psychiatry. Published online September 14, 2016.;():. doi:10.1001/jamapsychiatry.2016.1627.
September 14, 2016
Charles L. Raison, MD; Clemens W. Janssen, PhD; Christopher A. Lowry, PhD
1Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin–Madison2Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin–Madison
1Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin–Madison
3Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder
JAMA Psychiatry. Published online September 14, 2016.;():. doi:10.1001/jamapsychiatry.2016.1917.
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