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Comment & Response |

Hyperthermia for Major Depressive Disorder? ONLINE FIRST

Max Fink, MD1; Edward Shorter, PhD2
[+] Author Affiliations
1Stony Brook University School of Medicine, Saint James, New York
2University of Toronto, Medicine, History of Medicine Program, Toronto, Ontario, Canada
JAMA Psychiatry. Published online September 14, 2016. doi:10.1001/jamapsychiatry.2016.1627
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To the Editor The study by Janssen et al1 of a single exposure to whole-body hyperthermia relieving major depressive disorder is difficult to interpret and will need replication. The participants were highly selected from among long-time ill individuals with modest scores on the 17-item Hamilton Depression Rating Scale having less than 40% reduction with treatment. Which form of depression in the pool of “major depression” may be responsive to hyperthermia?

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September 14, 2016
Michael Berk, MD, PhD; Susannah Tye, PhD; Ken Walder, PhD; Sean McGee, PhD
1IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia2Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, the Florey Institute of Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
3Translational Neuroscience Lab, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota4Department of Psychiatry, University of Minnesota, Minneapolis
5Molecular and Medical Research SRC, School of Medicine, Faculty of Health, Deakin University, Waurn Ponds, Victoria, Australia
JAMA Psychiatry. Published online September 14, 2016.;():. doi:10.1001/jamapsychiatry.2016.1532.
September 14, 2016
Charles L. Raison, MD; Clemens W. Janssen, PhD; Christopher A. Lowry, PhD
1Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin–Madison2Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin–Madison
1Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin–Madison
3Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder
JAMA Psychiatry. Published online September 14, 2016.;():. doi:10.1001/jamapsychiatry.2016.1917.
August 1, 2016
Clemens W. Janssen, PhD; Christopher A. Lowry, PhD; Matthias R. Mehl, PhD; John J. B. Allen, PhD; Kimberly L. Kelly, MPA; Danielle E. Gartner, BA; Angelica Medrano, BA; Tommy K. Begay, PhD; Kelly Rentscher, MA; Joshua J. White, BS; Andrew Fridman, BS; Levi J. Roberts, BA; Megan L. Robbins, PhD; Kay-u Hanusch, MSc; Steven P. Cole, PhD; Charles L. Raison, MD
1Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin–Madison2Norton School of Family and Consumer Sciences, College of Agriculture, University of Arizona, Tucson
3Department of Integrative Physiology, Center for Neuroscience, University of Colorado–Boulder
4Department of Psychology, College of Science, University of Arizona, Tucson
5Department of Psychiatry, College of Medicine, University of Arizona, Tucson6School of Anthropology, University of Arizona, Tucson
5Department of Psychiatry, College of Medicine, University of Arizona, Tucson7Office of the Senior Vice President for Health Sciences, University of Arizona, Tucson
2Norton School of Family and Consumer Sciences, College of Agriculture, University of Arizona, Tucson5Department of Psychiatry, College of Medicine, University of Arizona, Tucson
1Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin–Madison2Norton School of Family and Consumer Sciences, College of Agriculture, University of Arizona, Tucson5Department of Psychiatry, College of Medicine, University of Arizona, Tucson
5Department of Psychiatry, College of Medicine, University of Arizona, Tucson8Midwestern University, Glendale, Arizona
5Department of Psychiatry, College of Medicine, University of Arizona, Tucson
9Department of Psychology, University of California, Riverside
10University of Applied Science Fresenius Idstein Medical School, Idstein, Germany
11Research Design Associates Inc, Yorktown Heights, New York
1Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin–Madison2Norton School of Family and Consumer Sciences, College of Agriculture, University of Arizona, Tucson5Department of Psychiatry, College of Medicine, University of Arizona, Tucson12Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin–Madison
JAMA Psychiatry. 2016;73(8):789-795. doi:10.1001/jamapsychiatry.2016.1031.
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