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Comment & Response |

Hyperthermia for Major Depressive Disorder?—Reply ONLINE FIRST

Charles L. Raison, MD1,2; Clemens W. Janssen, PhD1; Christopher A. Lowry, PhD3
[+] Author Affiliations
1Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin–Madison
2Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin–Madison
3Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder
JAMA Psychiatry. Published online September 14, 2016. doi:10.1001/jamapsychiatry.2016.1917
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In Reply We appreciate the insightful observations and questions raised by the letters from Fink and Shorter and Berk et al regarding our article.1 Here, we respond to each letter in turn.

Fink and Shorter query whether whole-body hyperthermia (WBH) might have appreciable efficacy for major depressive disorder (MDD) with melancholic features. To enter our randomized trial of WBH, participants had to meet DSM-IV-TR–defined MDD and to have a 17-item Hamilton Depression Rating Scale score of 16or greater. Thus, we did not select for individuals with melancholia as defined by the DSM. Here, we provide 2 somewhat conflicting observations.

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September 14, 2016
Michael Berk, MD, PhD; Susannah Tye, PhD; Ken Walder, PhD; Sean McGee, PhD
1IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia2Orygen, The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health, the Florey Institute of Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
3Translational Neuroscience Lab, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota4Department of Psychiatry, University of Minnesota, Minneapolis
5Molecular and Medical Research SRC, School of Medicine, Faculty of Health, Deakin University, Waurn Ponds, Victoria, Australia
JAMA Psychiatry. Published online September 14, 2016.;():. doi:10.1001/jamapsychiatry.2016.1532.
September 14, 2016
Max Fink, MD; Edward Shorter, PhD
1Stony Brook University School of Medicine, Saint James, New York
2University of Toronto, Medicine, History of Medicine Program, Toronto, Ontario, Canada
JAMA Psychiatry. Published online September 14, 2016.;():. doi:10.1001/jamapsychiatry.2016.1627.
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